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. 2023 Apr 28;11:70. doi: 10.1186/s40478-023-01571-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Signs of lysosomal storage material in frontal cortex of patients with FTD-GRN or sporadic FTLD-TDP type A. Patients with FTD-GRN exhibited a greater number of autofluorescent particles than controls in frontal cortex (ANOVA effect of group, p = 0.0243), while patients with sporadic FTLD-TDP type A did not differ from controls. c No difference was detected in autofluorescent particles in the occipital cortex of either group versus control (ANOVA effect of group, p = 0.4988). d, e Patients with FTD-GRN also exhibited a greater number of Sudan Black B-positive particles than controls in frontal cortex (ANOVA effect of group, p = 0.0022), as did patients with sporadic FTLD-TDP type A. f Levels of Sudan Black B-positive particles in occipital cortex of patients with FTD-GRN or FTLD-TDP type A did not significantly differ from controls (ANOVA effect of group, p = 0.0819). Scale bars in a, d represent 50 μm. *p < 0.05 and ***p < 0.001 by Fisher’s LSD post-hoc test. n = 5 controls, 13 patients with FTD-GRN, and 7 patients with sporadic FTLD-TDP type A