Fig. 6.

Patients with Sporadic FTLD-TDP Type C or Pick’s Disease Do Not Exhibit the Increased Lysosomal Gene Expression Observed in Patients with FTD-GRN or FTLD-TDP Type A. qPCR for a subset of lysosomal transcripts detected by Nanostring analysis (Fig. 2) generally validated their increased expression in frontal cortex of patients with FTD-GRN and sporadic FTLD-TDP type A (MANOVA effect of group, p = 0.01). However, none of these genes were significantly elevated from control in frontal cortex of patients with FTLD-TDP type C or Pick’s disease. *p < 0.05, **p < 0.01 by Tukey’s post-hoc test. Black lines and symbols indicate difference from control. Red lines and symbols indicate difference from FTD-GRN. n = 5 controls, 12 patients with FTD-GRN, 7 patients with FTLD-TDP type A, 7 patients with FTLD-TDP type C, and 7 patients with Pick’s disease