Table 1.
Blood-buccal cross-tissue correlations of blood-based DNA-methylation measures (n = 21)
| Mean differences | Cross-tissue correlation | ||||
|---|---|---|---|---|---|
| Mean | SD | 95% CI | p | r | |
| PhenoAge Accel | 45.03, 56.23 | < 0.001 | 0.25 | ||
| Blood | 7.25 | 8.35 | |||
| Buccal | 57.88 | 9.56 | |||
| GrimAge Accel | 12.02, 18.08 | < 0.001 | 0.48 | ||
| Blood | 19.04 | 4.93 | |||
| Buccal | 34.09 | 4.78 | |||
| DunedinPACE | 0.39, 0.50 | < 0.001 | 0.31 | ||
| Blood | 1.07 | 0.11 | |||
| Buccal | 1.52 | 0.06 | |||
| Epigenetic-g | – | – | 0.46 | ||
| Blood | 0 | 0.33 | |||
| Buccal | 0 | 0.23 | |||
Means, standard deviations (SD), and blood-buccal cross-tissue correlations of DNA-methylation measures of accelerated biological aging (i.e., PhenoAge Acceleration, GrimAge Acceleration), pace of aging (i.e., DunedinPACE), and DNAm-predicted cognitive performance (i.e., Epigenetic-g). Mean comparisons for Epigenetic-g are not possible because beta-methylation values are standardized prior to computation. Based on n = 21 people from Gene Expression Omnibus accession GSE11116 (chronological age mean = 32.24, SD = 16.05)