Table 1.
Participants’ demographics and clinical characteristics, stratified by remission status.
| Variables | Remission Status | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Remitters (N = 24, 60%) |
Remitters (N = 16, 40%) |
Fisher’s exact test |
t-test (DF = 38) |
MW-U test | |||||
| N (%) | Mean (SD) |
Median (IQR) |
N (%) |
Mean (SD) |
Median (IQR) |
(P) | t (P) | z (P) | |
| Treatment assignment | |||||||||
| SSRI (vs. Placebo) | 16 (67) | 6 (38) | 0.11 | ||||||
| Demographic | |||||||||
| Sex: F (vs. M) |
17 (71) |
11 (69) |
1.00 | ||||||
| Age (years) |
30.24 (14.20) |
24.30 (10.80) |
32.18 (17.44) |
22.95 (24.65) |
−0.39 (0.70) |
0.11 (0.91) |
|||
| Clinical | |||||||||
| Week0-HDRS |
19.33 (4.94) |
18.00 (5.00) |
15.56 (3.85) |
15.50 (4.50) |
2.57 (0.01*) |
2.30 (0.02*) |
|||
| Week1-HDRS |
15.92 (3.88) |
15.50 (5.50) |
13.50 (3.74) |
14 (5) |
1.96 (0.06) |
1.79 (0.07) |
|||
| Week8-HDRS |
14.42 (5.18) |
14.00 (6.50) |
4.53 (2.19) |
4.50 (3.50) |
7.19 (<0.01*) |
5.32 (<0.01*) |
|||
| ΔHDRS1 |
−0.20 (0.20) |
−0.19 (0.28) |
−0.15 (0.29) |
−0.22 (0.27) |
−0.61 (0.54) |
−0.07 (0.94) |
|||
| ΔHDRS8 |
−0.32 (0.30) |
−0.24 (0.41) |
−1.39 (0.75) |
−1.13 (0.48) |
6.30 (<0.01*) |
5.03 (<0.01*) |
|||
Non-Remitters: Week8-HDRS > 7. Remitters: Week8-HDRS ≤ 7.
HDRS Hamilton depression rating scale, Week0-HDRS Hamilton depression rating scale score at baseline, Week1-HDRS Hamilton depression rating scale score after first week of treatment, Week8-HDRS Hamilton depression rating scale score after eight weeks of treatment, ΔHDRS1: change in depression severity after first week of treatment, ln(Week1-HDRS/ Week0-HDRS), with a higher value indicating more depression symptoms and a lower value indicating improvement in depression. ΔHDRS8: change in depression severity after eight weeks of treatment, ln(Week8-HDRS/ Week0-HDRS), with a higher value indicating more depression symptoms and a lower value indicating improvement in depression. N sample size. DF degrees of freedom = 38 for all the variables in the t-test. MW-U test Mann–Whitney U test, SD standard deviation, IQR interquartile range (75th percentile – 25th percentile), SSRI selective serotonin reuptake inhibitor, F female, M male.
The P-values that are statistically significant are indicated in bold for *P < 0.05 at α = 0.05.