Table 2.
Results of the epigenome-wide association studies (EWAS). (A) CpG sites associated with birth urine MEOHP and MnBP concentration variables with gene and CpG island annotation. (B) Sex-specific results of CpG sites associated with birth urine MnBP concentration.
| CpG ID | Chr | Position | Coefficient (US) | p-value (US) | Coefficient (EW) | p-value (EW) | Coefficient (DK) | p-value (DK) | Coefficient (meta) | p-value (meta) | B-H adjusted | Gene annotation | CpG island annotation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (A) Urine MEOHP at birth | |||||||||||||
| cg12469381 | 7 | 29,519,297 | − 0.076 | 1.9E−03 | − 0.6 | 4.4E−06 | 0.078 | 5.4E−01 | − 0.36 | 5.0E−08 | 4.0E−02 | CHN2;CHN2 | – |
| Urine MnBP at birth | |||||||||||||
| cg11229715 | 2 | 225,441,832 | − 0.009 | 5.6E−01 | − 0.44 | 3.4E−06 | − 0.29 | 1.2E−05 | − 0.31 | 2.5E−08 | 2.0E−02 | CUL3 | – |
| CpG ID | Chr | Position | logFC | AveExpr | t | p-value | B-H adjusted p-value | Gene annotation | CpG island annotation | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (B) Urine MnBP at birth, females | |||||||||||||
| cg05353481 | 7 | 143,806,743 | 0.0339 | 0.8739 | 7.3136 | 6.5E−09 | 5.2E−03 | OR2A2 | – | ||||
| cg22290225 | 15 | 66,319,931 | 0.0141 | 0.5484 | 6.7664 | 3.8E−08 | 1.5E−02 | MEGF11 | ? | ||||
Chr: chromosome; B-H: Benjamini-Hochberg; –: No CpG island annotation matched.
?: unknown; –: No CpG island annotation matched.