Table 3.
Differentially methylated regions (DMRs) associated with phthalate concentration variables.
| Chr | Start | End | N | Estimate | SE | p-value | Adjusted p-value | Overlapping gene |
|---|---|---|---|---|---|---|---|---|
| Maternal urine MEOHP, late pregnancy | ||||||||
| Chr16 | 5,666,398 | 5,666,499 | 2 | − 0.1247 | 0.0272 | 4.7E-06 | 9.5E-03 | RP11-420N3.2 |
| Chr12 | 94,579,928 | 94,580,329 | 2 | 0.0799 | 0.0181 | 1.1E-05 | 2.2E-02 | PLXNC1 |
| Chr20 | 36,259,574 | 36,259,855 | 3 | 0.0922 | 0.0213 | 1.5E-05 | 3.1E-02 | |
| Chr20 | 4,942,894 | 4,943,173 | 2 | 0.1236 | 0.0292 | 2.4E-05 | 4.9E-02 | SLC23A2 |
| Chr9 | 131,682,859 | 131,683,132 | 3 | − 0.0650 | 0.0154 | 2.4E-05 | 4.9E-02 | |
| Urine MEOHP at birth | ||||||||
| Chr16 | 67,999,044 | 67,999,055 | 2 | − 0.2301 | 0.0479 | 1.6E-06 | 5.9E-03 | SLC12A4 |
| Chr11 | 65,357,780 | 65,358,078 | 2 | − 0.2406 | 0.0503 | 1.7E-06 | 6.6E-03 | EHBP1L1 |
| Chr14 | 36,946,996 | 36,947,368 | 2 | 0.2105 | 0.0444 | 2.2E-06 | 8.2E-03 | RP11-896J10.3;SFTA3 |
| Chr17 | 7,493,572 | 7,494,095 | 4 | − 0.1844 | 0.0401 | 4.3E-06 | 1.6E-02 | MPDU1 |
| Chr19 | 39,806,522 | 39,807,167 | 3 | − 0.1748 | 0.0381 | 4.4E-06 | 1.7E-02 | CTC-246B18.8 |
| Chr1 | 162,530,191 | 162,530,364 | 2 | − 0.2238 | 0.0491 | 5.3E-06 | 2.0E-02 | TBC1D7 |
| Chr6 | 13,295,922 | 13,295,976 | 3 | − 0.2343 | 0.0515 | 5.4E-06 | 2.0E-02 | RP11-359K18.3 |
| Chr3 | 157,807,441 | 157,807,694 | 2 | 0.2384 | 0.0529 | 6.7E-06 | 2.5E-02 | |
| Chr19 | 44,952,808 | 44,953,124 | 2 | − 0.2087 | 0.0464 | 6.8E-06 | 2.6E-02 | |
| Chr14 | 70,883,847 | 70,884,510 | 8 | − 0.1323 | 0.0296 | 8.1E-06 | 3.1E-02 | |
| Chr10 | 1,438,165 | 1,438,548 | 2 | − 0.2264 | 0.0508 | 8.2E-06 | 3.1E-02 | ADARB2 |
| Chr15 | 40,630,371 | 40,630,791 | 2 | − 0.1821 | 0.0414 | 1.1E-05 | 4.2E-02 | C15orf52 |
| Chr6 | 31,760,426 | 31,760,593 | 2 | − 0.2210 | 0.0504 | 1.2E-05 | 4.4E-02 | VARS |
| Maternal urine MEHHP, late pregnancy | ||||||||
| Chr3 | 69,249,276 | 69,249,718 | 2 | 0.0547 | 0.0120 | 4.8E-06 | 9.5E-03 | FRMD4B |
| Chr8 | 6,481,582 | 6,481,608 | 2 | − 0.1298 | 0.0289 | 7.1E-06 | 1.4E-02 | MCPH1;CTD-2541M15.1 |
| Chr16 | 5,666,398 | 5,666,499 | 2 | − 0.1133 | 0.0258 | 1.1E-05 | 2.2E-02 | RP11-420N3.2 |
| Chr12 | 94,579,928 | 94,580,329 | 2 | 0.0751 | 0.0172 | 1.2E-05 | 2.4E-02 | PLXNC1 |
| Chr9 | 131,682,737 | 131,683,044 | 3 | − 0.0630 | 0.0145 | 1.5E-05 | 2.9E-02 | |
| Urine MEHHP at birth | ||||||||
| Chr16 | 67,999,044 | 67,999,055 | 2 | − 0.2258 | 0.0469 | 1.5E-06 | 3.5E-03 | SLC12A4 |
| Chr19 | 39,806,522 | 39,807,167 | 3 | − 0.1744 | 0.0369 | 2.3E-06 | 5.5E-03 | CTC-246B18.8 |
| Chr11 | 65,357,780 | 65,358,078 | 2 | − 0.2309 | 0.0493 | 2.8E-06 | 6.5E-03 | EHBP1L1 |
| Chr13 | 39,358,777 | 39,358,795 | 2 | − 0.2349 | 0.0512 | 4.4E-06 | 1.0E-02 | FREM2 |
| Chr14 | 36,946,996 | 36,947,368 | 2 | 0.1932 | 0.0436 | 9.6E-06 | 2.2E-02 | RP11-896J10.3;SFTA3 |
| Chr14 | 70,883,847 | 70,884,204 | 5 | − 0.1434 | 0.0324 | 9.6E-06 | 2.2E-02 | |
| Chr19 | 44,952,808 | 44,953,124 | 2 | − 0.1982 | 0.0449 | 1.0E-05 | 2.3E-02 | |
| Chr1 | 200,841,769 | 200,841,805 | 2 | − 0.2098 | 0.0478 | 1.2E-05 | 2.7E-02 | |
| Chr9 | 136,200,708 | 136,201,061 | 2 | − 0.1863 | 0.0432 | 1.6E-05 | 3.8E-02 | SURF6 |
| Chr7 | 158,613,567 | 158,614,019 | 2 | − 0.2341 | 0.0544 | 1.7E-05 | 4.0E-02 | ESYT2 |
| Chr12 | 4,918,169 | 4,919,230 | 10 | 0.1982 | 0.0464 | 1.9E-05 | 4.5E-02 | GALNT8;KCNA6 |
| Maternal urine MnBP, late pregnancy | ||||||||
| Chr9 | 131,682,737 | 131,683,132 | 4 | − 0.0546 | 0.0106 | 2.4E-07 | 1.2E-03 | |
| Chr12 | 133,406,047 | 133,406,309 | 2 | − 0.0458 | 0.0096 | 1.8E-06 | 9.0E-03 | CHFR |
| Chr15 | 34,394,035 | 34,394,207 | 3 | − 0.0866 | 0.0188 | 4.3E-06 | 1.6E-02 | EMC7 |
| Chr16 | 30,816,719 | 30,816,924 | 2 | − 0.0765 | 0.0169 | 5.9E-06 | 9.2E-02 | |
| Chr6 | 170,038,695 | 170,038,733 | 2 | 0.0825 | 0.0184 | 7.5E-06 | 3.7E-02 | WDR27 |
| Chr10 | 7,708,869 | 7,708,934 | 2 | − 0.0822 | 0.0186 | 9.5E-06 | 4.7E-02 | ITIH5 |
| Urine MnBP at birth | ||||||||
| Chr4 | 1,363,008 | 1,363,182 | 2 | − 0.1577 | 0.0311 | 3.9E-07 | 2.1E-03 | UVSSA |
| Chr19 | 39,806,522 | 39,807,167 | 3 | − 0.1335 | 0.0284 | 2.6E-06 | 1.4E-02 | CTC-246B18.8 |
| Chr6 | 32,406,271 | 32,406,521 | 2 | − 0.1922 | 0.0412 | 3.1E-06 | 1.7E-02 | |
| Chr10 | 132,887,109 | 132,887,552 | 2 | − 0.1635 | 0.0356 | 4.5E-06 | 2.4E-02 | |
| Chr15 | 55,489,541 | 55,489,544 | 2 | − 0.1905 | 0.0425 | 7.3E-06 | 3.9E-02 | |
| Maternal urine DEHP, late pregnancy | ||||||||
| Chr16 | 5,666,398 | 5,666,499 | 2 | − 0.1219 | 0.0268 | 5.6E-06 | 1.1E-02 | RP11-420N3.2 |
| Chr12 | 94,579,928 | 94,580,329 | 2 | 0.0782 | 0.0179 | 1.2E-05 | 2.5E-02 | PLXNC1 |
| Chr8 | 6,481,582 | 6,481,608 | 2 | − 0.1316 | 0.0302 | 1.3E-05 | 2.7E-02 | MCPH1; CTD-2541M15.1 |
| Chr3 | 69,249,276 | 69,249,718 | 2 | 0.0542 | 0.0125 | 1.4E-05 | 2.7E-02 | FRMD4B |
| Chr9 | 131,682,737 | 131,683,044 | 3 | − 0.0659 | 0.0151 | 1.4E-05 | 2.7E-02 | |
| Chr20 | 36,259,574 | 36,259,855 | 3 | 0.0885 | 0.0210 | 2.5E-05 | 5.0E-02 | |
| Urine DEHP at birth | ||||||||
| Chr16 | 67,999,044 | 67,999,055 | 2 | − 0.2365 | 0.0482 | 9.3E-07 | 3.0E-03 | SLC12A4 |
| Chr11 | 65,357,780 | 65,358,078 | 2 | − 0.2458 | 0.0507 | 1.2E-06 | 3.9E-03 | EHBP1L1 |
| Chr19 | 39,806,522 | 39,807,167 | 3 | − 0.1808 | 0.0381 | 2.1E-06 | 6.9E-03 | CTC-246B18.8 |
| Chr14 | 36,946,996 | 36,947,368 | 2 | 0.2112 | 0.0447 | 2.3E-06 | 7.3E-03 | RP11-896J10.3; SFTA3 |
| Chr17 | 7,493,572 | 7,494,095 | 4 | − 0.1824 | 0.0405 | 6.5E-06 | 2.1E-02 | MPDU1 |
| Chr14 | 70,883,847 | 70,884,510 | 8 | − 0.1339 | 0.0297 | 6.6E-06 | 2.1E-02 | |
| Chr19 | 44,952,808 | 44,953,124 | 2 | − 0.2084 | 0.0464 | 7.1E-06 | 2.3E-02 | |
| Chr6 | 13,295,922 | 13,295,976 | 3 | − 0.2323 | 0.0519 | 7.5E-06 | 2.4E-02 | TBC1D7 |
| Chr6 | 31,760,426 | 31,760,593 | 2 | − 0.2249 | 0.0505 | 8.5E-06 | 2.7E-02 | VARS |
| Chr1 | 162,530,191 | 162,530,364 | 2 | − 0.2192 | 0.0496 | 9.7E-06 | 3.1E-02 | RP11-359K18.3 |
| Chr10 | 1,438,165 | 1,438,548 | 2 | − 0.2246 | 0.0509 | 1.0E-05 | 3.3E-02 | ADARB2 |
| Chr16 | 1,824,041 | 1,824,177 | 2 | − 0.2453 | 0.0565 | 1.4E-05 | 4.5E-02 | EME2 |
| Chr1 | 200,841,769 | 200,841,805 | 2 | − 0.2149 | 0.0496 | 1.5E-05 | 4.7E-02 | |
n: number of CpGs; SE: standard error.