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. 2023 Apr 29;23:223. doi: 10.1186/s12872-023-03227-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overview of the current and future applications of human iPSCs technology in the research for large-vessels stroke (LVS) and small vessel diseases (SVD) to develop relevant vascular models, made of vascular smooth muscle cells (VSMC), endothelial cells (ECs) and brain microvascular endothelial cells (BMEC) to model the disease ‘in a dish’ and identify new therapeutic targets for future treatments of stroke. (BBB = blood brain barrier; OoC = Organ-on-Chip). Parts of the figure were drawn by using pictures from Servier Medical Art (http://smart.servier.com/), licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/)