Table 2.

The Predicted Biological Targets Involved in Mediating Malvaviscus arboreus Anti-Cancer Activity Using SWISS Target Prediction, Sea Search, and Molinspiration Web Servers

Compound Name	Target Predictions
	SWISS Target Prediction	SEA Search	Molinspiration
Astragalin	Carbonic anhydrase	Carbonic anhydrase	GPCR ligand	0.06
			Ion channel modulator	−0.05
			Kinase inhibitor	0.10
			Nuclear receptor ligand	0.20
			Protease inhibitor	−0.05
			Enzyme inhibitor	0.41
4-hydroxyphenyl acetic acid	Carbonic anhydrase	Carbonic anhydrase	GPCR ligand	−0.53
			Ion channel modulator	−0.07
			Kinase inhibitor	−1.02
			Nuclear receptor-ligand	−0.18
			Protease inhibitor	−0.69
			Enzyme inhibitor	−0.09
Caffeic acid	Carbonic anhydrase	Carbonic anhydrase	GPCR ligand	−0.48
			Ion channel modulator	−0.23
			Kinase inhibitor	−0.81
			Nuclear receptor-ligand	−0.10
			Protease inhibitor	−0.79
			Enzyme inhibitor	−0.09
Vernolic acid	Cytochrome P450	Cannabinoid receptors	GPCR ligand	0.34
			Ion channel modulator	0.15
			Kinase inhibitor	0.10
			Nuclear receptor ligand	0.52
			Protease inhibitor	0.59
			Enzymeinhibitor	0.60