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Analysis Results of Lipinski’s Rule of Five
| Rule | Parameters | Ligands | ||
|---|---|---|---|---|
| Apigenin-7-Glucuronide | Dihydrokaempferol-3-Glucoside | Esculetin | ||
| Lipinski’s Rule of Five | Molecular mass (Less than 500 Dalton) | 437 | 439 | 178 |
| Hydrogen bond donor (Less than 5) | 2 | 3 | 2 | |
| Hydrogen bond acceptors (Less than 10) | 19 | 22 | 9 | |
| LogP (Less than 5) | 2.15 | 1.91 | 1.2 | |
| Molar Refractivity (40–130) | 97.65 | 94.89 | 46.53 | |
| Violation | 1 | 1 | 0 | |
| Drug-likeness | Yes | Yes | Yes | |
