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. 2023 Apr 26;16:1193–1205. doi: 10.2147/DMSO.S407177

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© 2023 Ren et al.

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Upregulation of SphK1 abolishes the effects of BA on cell viability and apoptosis in HG-treated HK-2 cells. (A–E) SphK1 protein expression (A), S1P, p65, and p-p65 protein levels (B), CCK-8 assay of cell viability (C), LDH activity (D), and TUNEL assay of apoptosis (E) in HK-2 cells transfected with or without ov-SphK1 before treatment with HG (30 mM) or HG+BA (10 µM). *P<0.05, **P<0.01, and ***P<0.001 vs control; ^#P<0.05, ^##P<0.01, and ^###P<0.001 vs HG treatment; ^&P<0.05 and ^&&P<0.01 vs HG+BA treatment.

Abbreviation: LDH, lactate dehydrogenase.