Figure 6.

Overlap in genetic signals with diseases and other complex traits. Arteries in red, veins in blue, combined-vessel signal in black: number of variants shared with other traits reported in the genome-wide association study Catalog⁷⁰ (also considering single nucleotide polymorphisms [SNPs] in high linkage disequilibrium with the lead SNP, r² > 0.8). Only traits with ≥ 5 shared associations are included (for a full list, including rsIDs, refer to the Supplemental Dataset 3). The traits with the highest number of shared SNPs belong to metabolic syndrome (blood pressure, body mass index [BMI], blood cholesterol levels) and cardiovascular disease (CVD). This analysis was generated using functional mapping and annotation of genetic associations (FUMA).¹⁰⁴ DBP = diastolic blood pressure; IBD = inflammatory bowel disease; MCHC = mean corpuscular hemoglobin concentration; PSC = primary sclerosing cholangitis; SBP = systolic blood pressure; SLE = systemic lupus erythematosus; SNP = single nucleotide polymorphism; T1 = type 1; T2 = type 2.