Table 4.

Half-maximum inhibitory concentrations (IC₅₀)^a in µM of complexes 1 and 2 and the free ligands dpa and Bndpa for A549 (lung adenocarcinoma) and A375 (melanoma) human cells, after incubation of 48 h at 37 °C

Complex	A549			A375
	Darkb	Irradiatedc	PId	Darkb	Irradiatedc	PId
1	> 100	2.11 ± 0.58	> 50	> 100	1.15 ± 0.46	> 100
2	> 100	> 100	–	> 100	> 100	–
dpa	> 100	> 100	–	> 100	> 100	–
Bndpa	> 100	> 100	–	> 100	> 100	–

^aThe results are expressed as mean values ± SD out of three independent experiments (Fig. S39)

^bDark conditions: before the 48-h incubation, the compounds were incubated with cells for 1 h at 37 °C, to allow cell uptake, and another hour at RT protected from light

^cPre-irradiation conditions: before the 48-h incubation, the compounds were incubated with cells for 1 h at 37 °C, to allow cell uptake, and an additional hour at RT under irradiation (700–400 nm light)

^dPI = phototoxic index obtained by IC₅₀(dark)/IC₅₀(irr)