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. 2023 Apr 30;4(3):e252. doi: 10.1002/mco2.252

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© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Transient sleep deprivation induced changes in multiple‐omics molecular and physiological indicators. (A) Basic procedures for sleep deprivation experiments. (B) The statistical analysis of multiomics molecules on day 2 and day 3 relative to baseline (day 1). (C) Principal component analysis (PCA) revealed changes in the data distribution of genes, proteins and metabolites after sleep deprivation. (D) Difference analysis of physiological indicators (heart rate, blood pressure, blood glucose and lipids, liver and kidney function, and blood routine) after sleep deprivation.