Table 2.
Disease characteristics stratified by presence of separate tumor nodules
| Variable | Level | No separate tumor nodules (n=44,558) |
Separate tumor nodules in ipsilateral lung (n=1,284) |
Total (n=45,842) |
p-value |
|---|---|---|---|---|---|
|
| |||||
| Primary Site | Lower lobe, lung | 13942 (97.44%) | 366 (2.56%) | 14308 (31.21%) | |
| Main | 590 (95.16%) | 30 (4.84%) | 620 (1.35%) | ||
| bronchus\Overlapping\NOS | 0.0004 | ||||
| Middle lobe, lung | 2589 (97.81%) | 58 (2.19%) | 2647 (5.77%) | ||
| Upper lobe, lung | 27437 (97.06%) | 830 (2.94%) | 28267 (61.66%) | ||
|
| |||||
| Laterality | Origin of primary is left | 17463 (97.22%) | 500 (2.78%) | 17963 (39.18%) | 0.8560 |
| Origin of primary is right | 27095 (97.19%) | 784 (2.81%) | 27879 (60.82%) | ||
|
| |||||
| Tumor Size | < 1 cm | 1371 (97.17%) | 40 (2.83%) | 1411 (3.08%) | 0.0001 |
| >= 1 cm, < 3 cm | 26540 (97.31%) | 733 (2.69%) | 27273 (59.49%) | ||
| >= 3 cm | 4746 (96.19%) | 188 (3.81%) | 4934 (10.76%) | ||
| Unknown, size not stated | 11901 (97.36%) | 323 (2.64%) | 12224 (26.67%) | ||
|
| |||||
| Grade | Well differentiated, NOS | 8259 (97.41%) | 220 (2.59%) | 8479 (18.5%) | 0.5405 |
| Moderately differentiated | 21926 (97.13%) | 647 (2.87%) | 22573 (49.24%) | ||
| Poorly differentiated | 11555 (97.19%) | 334 (2.81%) | 11889 (25.93%) | ||
| Undifferentiated | 154 (95.65%) | 7 (4.35%) | 161 (0.35%) | ||
| Unknown | 2664 (97.23%) | 76 (2.77%) | 2740 (5.98%) | ||
|
| |||||
| Histology Category | Adenocarcinoma | 33028 (96.84%) | 1076 (3.16%) | 34104 (74.39%) | <0.0001 |
| Large cell | 962 (96.98%) | 30 (3.02%) | 992 (2.16%) | ||
| Squamous cell carcinoma | 10568 (98.34%) | 178 (1.66%) | 10746 (23.44%) | ||
|
| |||||
| Pathologic T-Stage | Unknown | 582 (97.82%) | 13 (2.18%) | 595 (1.3%) | <0.0001 |
| pT0/p1 | 33724 (99.6%) | 134 (0.4%) | 33858 (73.86%) | ||
| pT2 | 9728 (99.42%) | 57 (0.58%) | 9785 (21.35%) | ||
| pT3 | 489 (32.13%) | 1033 (67.87%) | 1522 (3.32%) | ||
| pT4 | 35 (42.68%) | 47 (57.32%) | 82 (0.18%) | ||
|
| |||||
| Pathologic N-Stage | Unknown | 1008 (97.3%) | 28 (2.7%) | 1036 (2.26%) | <0.0001 |
| pN0 | 38985 (97.53%) | 988 (2.47%) | 39973 (87.2%) | ||
| pN1 | 2836 (95.23%) | 142 (4.77%) | 2978 (6.5%) | ||
| pN2 | 1729 (93.21%) | 126 (6.79%) | 1855 (4.05%) | ||
|
| |||||
| Pleural Invasion | Unknown | 5778 (97.95%) | 121 (2.05%) | 5899 (12.87%) | <0.0001 |
| No | 32397 (97.46%) | 843 (2.54%) | 33240 (72.51%) | ||
| Yes | 6382 (95.23%) | 320 (4.77%) | 6702 (14.62%) | ||
|
| |||||
| Lymph Vascular Invasion | Not present | 35629 (97.53%) | 902 (2.47%) | 36531 (80.41%) | <0.0001 |
| Present | 5770 (95.26%) | 287 (4.74%) | 6057 (13.33%) | ||
| Unknown | 2753 (96.9%) | 88 (3.1%) | 2841 (6.25%) | ||