Table 2.

Relative rate of health-related late mortality and association with modifiable lifestyle and cardiovascular risk factors among CCSS participants who completed at least one survey at age ≥18 years

	Health-related cause			Subsequent neoplasm			Cardiac			Pulmonary			Other
	RR	95% CI	p-value	RR	95% CI	p-value	RR	95% CI	p-value	RR	95% CI	p-value	RR	95% CI	p-value
Healthy lifestyle score
Unhealthy (0-2)	Ref			Ref			Ref			Ref			Ref
Moderate (2·5-3)	0·9	0·8 - 1·0	0·031	0·9	0·7 - 1·1	0·25	0·9	0·7 - 1·2	0·45	0·8	0·5 - 1·4	0·47	0·8	0·6 - 1·0	0·11
Healthy (3·5-4)	0·8	0·7 - 0·9	0·002	0·9	0·8 - 1·2	0·57	0·8	0·5 - 1·2	0·26	0·6	0·3 - 1·1	0·093	0·5	0·3 - 0·7	<·001
Cardiovascular risk factors
Hypertension No vs. Yes	0·7	0·6 - 0·8	<·001	0·9	0·7 - 1·1	0·33	0·7	0·5 - 1·0	0·053	0·7	0·4 - 1·1	0·13	0·5	0·3 - 0·6	<·001
Diabetes No vs. Yes	0·7	0·6 - 0·9	<·001	0·9	0·7 - 1·3	0·65	0·5	0·3 - 0·8	0·004	0·7	0·3 - 1·4	0·27	0·6	0·4 - 0·9	0·007
Dyslipidemia No vs. Yes	1·2	1·0 - 1·4	0·059	0·9	0·8 - 1·2	0·64	1·2	0·8 - 1·8	0·29	1·9	0·9 - 3·8	0·070	1·5	1·0 - 2·1	0·036

Relative rates are adjusted for treatment exposures: cranial irradiation dose, chest irradiation dose, anthracycline dose, and alkylating agent dose, and sociodemographic factors including: age at diagnosis, race/ethnicity, sex, and attained age, education, income, and insurance status.

Lifestyle factors, including smoking status, alcohol use, physical activity, and unhealthy weight, were assigned a score of 0 (unhealthy) to 1 (healthy) and combined to create a lifestyle score ranging from 0-4 which was further categorized as unhealthy (0-2), moderately healthy (2·5-3), and healthy (3·5-4).

Covariates presented in the table (lifestyle category and chronic conditions) and socioeconomic factors (education, income, insurance) factors were included in the model as time-dependent variables.