Table 1.
Demographic features and clinical manifestations on first presentation of 36 patients diagnosed with anti-mGluR1 encephalitis.
| Case number | References | Age/gender | Prodromal Symptoms | Associated malignancy | Clinical manifestations on first presentation |
|---|---|---|---|---|---|
| 1 | Sillevis Smitt et al. (11) | 19/F | None | Hodgkin’s lymphoma | Cerebellar syndrome |
| 2 | Sillevis Smitt et al. (11) | 49/F | None | Hodgkin’s lymphoma | Cerebellar syndrome and cognitive decline |
| 3 | Marignier et al. (10) | 50/F | Yes | None | Cerebellar syndrome and headache |
| 4 | Lancaster et al. (9) | 69/M | None | None | Cerebellar syndrome |
| 5 | Iorio et al. (20) | 65/M | None | Mycosis fungoides and prostate adenocarcinoma | Cerebellar syndrome and cognitive decline |
| 6 | Lopez-Chiriboga et al. (4) | 64/M | None | None | Cerebellar ataxia |
| 7 | Lopez-Chiriboga et al. (4) | 54/M | None | None | Cerebellar ataxia |
| 8 | Lopez-Chiriboga et al. (4) | 81/M | None | None | Cerebellar ataxia and cognitive impairment |
| 9 | Lopez-Chiriboga et al. (4) | 77/M | None | None | Cerebellar ataxia |
| 10 | Lopez-Chiriboga et al. (4) | 51/M | None | Testicular seminoma | Psychiatric symptoms and dysgeusia |
| 11 | Lopez-Chiriboga et al. (4) | 60/F | None | None | Dysgeusia |
| 12 | Lopez-Chiriboga et al. (4) | 58/F | None | None | Cerebellar syndrome and dysgeusia |
| 13 | Lopez-Chiriboga et al. (4) | 67/M | None | Cutaneous T-cell lymphoma | Cerebellar ataxia |
| 14 | Lopez-Chiriboga et al. (4) | 67/F | None | None | Paresthesia, vertigo, and dysgeusia |
| 15 | Lopez-Chiriboga et al. (4) | 33/F | None | Acute lymphocytic leukemia | Cerebellar syndrome and cognitive impairment |
| 16 | Lopez-Chiriboga et al. (4) | 77/F | None | Mantle cell non-Hodgkin’s lymphoma | Ataxia, spastic paresis, and cognitive impairment |
| 17 | Yoshikura et al. (2) | 61/F | None | None | Cerebellar syndrome and dysphagia |
| 18 | Pedroso et al. (21) | 39/F | None | None | Behavioral changes, catatonia, and cerebellar syndrome |
| 19 | Christ et al. (12) | 45/M | None | None | Dysarthria |
| 20 | Gollion et al. (13) | 64/M | None | None | Cerebellar ataxia and myoclonic jerks |
| 21 | Chaumont et al. (14) | 22/F | Yes | None | Cough, headache, and cerebellar syndrome |
| 22 | Spatola et al. (15) | 29/M | Yes | None | Sleeping difficulties |
| 23 | Spatola et al. (15) | 22/F | Yes | None | Cerebellar syndrome, fever, hallucinations, and cognitive decline |
| 24 | Spatola et al. (15) | 45/F | Yes | None | Slowness in writing, hypophonia, and cerebellar syndrome |
| 25 | Spatola et al. (15) | 59/M | None | None | Cerebellar syndrome |
| 26 | Spatola et al. (15) | 54/M | Yes | None | Visual loss, cerebellar syndrome, behavioral changes |
| 27 | Spatola et al. (15) | 56/M | None | None | Behavioral changes and cognitive decline |
| 28 | Spatola et al. (15) | 62/M | None | Sarcoma | Gait instability |
| 29 | Spatola et al. (15) | 24/M | None | Hodgkin’s lymphoma | Cerebellar syndrome |
| 30 | Spatola et al. (15) | 49/F | None | None | Focal seizures and impaired level of consciousness |
| 31 | Spatola et al. (15) | 6/M | Yes | None | Cerebellar syndrome, tremor and choreiform movements. |
| 32 | Bien et al. (16) | 3/M | None | None | Unsteady gait |
| 33 | Chandler et al. (17) | 5/F | Yes | None | Nausea, vomiting, abdominal pain, fever, headache and altered mental status and cerebellar syndrome |
| 34 | Vinke et al. (18) | 50/F | None | None | Seizures and hallucinations |
| 35 | Goh et al. (19) | 15/M | None | None | Cerebellar syndrome |
| 36 | Current case | 56/F | Yes | None | Febrile illness followed by cerebellar syndrome |
M, male; F, female.