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. 2023 Apr 17;17:1155929. doi: 10.3389/fncel.2023.1155929

FIGURE 5.

FIGURE 5

Age-dependent strength loss but absence of motor deficits in C9ORF72 deficient mice. (A) Rotarod testing of C9ORF72 deficient mice at 2, 5, 9, 12, and 22 months (wild-type n = 10; miR-Scramble n = 12, miR-C9orf72 n = 34). No differences of sensorimotor coordination, or motor learning were observed across trials in young or aged animals. (B) Quantification of normal step number and stride length by Treadmill. No alteration could be seen with C9ORF72 deficient animals (wild-type n = 10; miR-Scramble n = 12, miR-C9orf72 n = 34). (C) Hind limb grip strength measured at 2, 5, 9, 12, 15, and 22 months (wild-type n = 10; miR-Scramble n = 12, miR-C9orf72 n = 34). (D) Hanging wire test measuring time to fall at 2, 5, 9, 12, and 15 months (wild-type n = 10; miR-Scramble n = 12, miR-C9orf72 n = 34). Error bars represent SEM; *p < 0.05, **p < 0.01, ****p < 0.0001.