FIGURE 3.

Reduced C9orf72 expression exacerbates polyGR₁₅ toxicity in induced pluripotent stem cell (iPSC)-derived motor neurons. (A) Neuronal survival 24 h after exogenous treatment with polyGR₁₅ ranging from 10 nM to 10 μM or 0.1% DMSO control. Values were normalized to vehicle treated wells for each cell line. (B) Neuronal survival 48 h after exogenous treatment with polyGR₁₅ or 0.1% DMSO control. Values were normalized to vehicle treated wells for each cell line. Data are presented as mean values ± standard deviations (error bars).