FIGURE 5.

Protein arginine methyltransferase inhibition rescues polyGR₁₅-induced toxicity in C9orf72-expanded motor neurons. Survival of spinal motor neurons 24 days post-plating following co-treatment with 1 μM polyGR₁₅ and concentrations of MS023 ranging from 1 nM to 10 μM. **Denotes p < 0.01, and ***denotes p < 0.001 (comparing MS023 co-treated groups to polyGR₁₅ alone by two-way ANOVA analysis of variance followed by Dunnett’s test). Data are presented as mean values ± standard deviations (error bars).