. 2023 Apr 17;17:1134090. doi: 10.3389/fncel.2023.1134090

TABLE 1.

Statistical testing of data in Figure 3 indicates significant differences C9^(+/+) parental (Pt. 337) and edited lines following exposure to PolyGR₁₅¹.

Endpoint	Cell line vs. C9^(+/+) parental	10 μM	5.618 μM	3.156 μM	1.773 μM	0.996 μM	0.56 μM	0.314 μM	0.177 μM	0.099 μM	Vehicle	IC50	R²
24 h	C9^(+/+) parental	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	49.07	0.54
24 h	C9^(–/+) TD6 A2	NS	^*	^**	NS	^**	NS	Ns	NS	NS	NS	20.04	0.75
24 h	C9^(–/–) TD6 F2	^****	^****	^****	^****	^****	^****	^**	NS	NS	NS	4.225	0.85
24 h	C9^(–/–) TD6 G11	^*	^****	^****	^****	^****	^**	Ns	NS	NS	NS	8.411	0.80
24 h	C9^(–/+) Expanded Pt. 137	^***	^****	^****	^****	^****	^**	Ns	NS	NS	NS	7.394	0.80
48 h	C9^(+/+) parental	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	46.53	0.67
48 h	C9^(–/+) TD6 A2	NS	NS	^*	NS	^*	NS	NS	NS	NS	NS	5.027	0.72
48 h	C9^(–/–) TD6 F2	^****	^****	^****	^****	^****	^****	^**	NS	NS	NS	2.675	0.90
48 h	C9^(–/–) TD6 G11	^***	^***	^****	^**	^**	NS	Ns	NS	NS	NS	12.86	0.85
48 h	C9^(–/+) Expanded Pt. 137	^****	^****	^****	^****	^****	^****	^***	^**	NS	NS	2.227	0.91

¹*Denotes p < 0.05, **denotes p < 0.01, ***denotes p < 0.001, and ****denotes p < 0.0001 comparing changes in neuronal survival at each concentration compared to C9^(+/+) parental by two-way ANOVA analysis of variance followed by Dunnett’s test. IC50s were calculated using a four-parameter logistical regression model.