Table 5.
Univariable and multivariable predictors of RV-PA coupling impairment (binary logistic regression).
| Univariable regression analysis | Pre TAVI | Post TAVI | ||
|---|---|---|---|---|
| OR | p-value | OR | p-value | |
| Age | 0.940 | 0.028 | 0.952 | 0.044 |
| Atrial fibrillation | 3.980 | 0.001 | 9.389 | <0.001 |
| AVAi | 0.048 | 0.009 | 0.406 | 0.102 |
| Bicuspid | 3.170 | 0.001 | 3.786 | 0.999 |
| LVMi | 1.005 | 0.129 | 1.009 | 0.043 |
| LVEF | 0.947 | <0.001 | 0.951 | 0.008 |
| LV-GLS* | 1.305 | <0.001 | 1.290 | <0.001 |
| E/A* | 14.46 | <0.001 | 4.689 | 0.020 |
| LAVi | 1.051 | <0.001 | 1.046 | 0.001 |
| LAAi | 1.315 | <0.001 | 1.251 | 0.001 |
| LA-GLS | 0.803 | <0.001 | 0.845 | <0.001 |
| TAPSE | 0.820 | <0.001 | 0.900 | 0.030 |
| S’RV* | 0.715 | <0.001 | 1.003 | 0.902 |
| FAC* | 0.942 | 0.011 | 0.897 | <0.001 |
| PASP* | 1.156 | <0.001 | 1.140 | <0.001 |
| PAPm* | 1.267 | <0.001 | 1.239 | <0.001 |
| RA | 1.149 | <0.001 | 1.107 | <0.001 |
| RV | 1.179 | <0.001 | 1.139 | <0.001 |
| Tricuspid regurgitation | 1.687 | 0.017 | 1.750 | 0.024 |
| RV-GLS* | 1.483 | <0.001 | 1.480 | <0.001 |
| RV-FWLS* | 1.434 | <0.001 | 1.361 | <0.001 |
| RV-IVS* | 1.181 | <0.001 | 1.227 | <0.001 |
| Multivariable regression analysis—Model 1 (Pre TAVI) | ||||
| LA-GLS | 0.837 | <0.001 | ||
| RA | 1.111 | 0.003 | ||
| Multivariable regression analysis—Model 2 (Post TAVI) | ||||
| Age | 0.931 | 0.040 | ||
| LA-GLS | 0.848 | <0.001 | ||
| RV | 1.174 | 0.002 | ||
AVA, aortic valve area; AVAi, aortic valve area index; LVEF, left ventricle ejection fraction; LV-GLS, left ventricle global longitudinal strain; LA, left atrium; LAAi, LA area index; LAVi, LA volume index; LVMi, LV mass index; LA-GLS, LA global longitudinal strain; TAPSE, tricuspid annular plane systolic excursion; S`RV, peak systolic myocardial velocity at the lateral site of the tricuspid annulus; PAPS, systolic pulmonary artery pressure; PAPm, mean pulmonary artery pressure; FAC, right ventricle fractional area change; RA-right atrium; RV, right ventricle RV-GLS, RV global longitudinal strain; RV-FWLS, RV free wall longitudinal strain; RV-IVS, RV interventricular septum strain. Model 1—Multivariable analysis (Backward Wald)—variables: age, atrial fibrillation, AVAi, bicuspid, LAVi, LA-GLS, LVEF, RA, RV, tricuspid regurgitation. Model 2—Multivariable analysis (Backward Wald)—variables: age, atrial fibrillation, LAVi, LV mass index, LA-GLS, LVEF, RA, RV, tricuspid regurgitation.
*Variables highly correlated with another variable (Pearson coefficient > 0.6), not included.