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. 2023 Apr 17;11:1122773. doi: 10.3389/fped.2023.1122773

Table 3.

Association between n-3 PUFA intakes and the risk of juvenile myopia.

Variables Model 1 Model 2 Model 3
OR (95% CI) P OR (95% CI) P OR (95% CI) P
High myopia vs. normal vision
Energy density
n-3 PUFA
<759.65 Ref Ref Ref
≥759.65 0.51 (0.23–1.12) 0.092 0.51 (0.24–1.07) 0.076 0.44 (0.19–1.02) 0.056
ALA
<637.85 Ref Ref Ref
≥637.85 0.96 (0.33–2.84) 0.946 0.97 (0.32–2.91) 0.952 0.91 (0.24–3.39) 0.886
SDA
<7.51 Ref Ref Ref
≥7.51 0.82 (0.33–2.08) 0.678 0.82 (0.33–2.07) 0.678 0.83 (0.33–2.08) 0.684
EPA
<11 Ref Ref Ref
≥11 0.37 (0.17–0.81) 0.014 0.38 (0.17–0.84) 0.017 0.39 (0.18–0.85) 0.018
DPA
<8.18 Ref Ref Ref
≥8.18 1.12 (0.44–2.84) 0.811 1.10 (0.44–2.75) 0.844 1.10 (0.43–2.83) 0.846
DHA
<31.4 Ref Ref Ref
≥31.4 0.72 (0.25–2.08) 0.533 0.73 (0.25–2.15) 0.562 0.74 (0.25–2.18) 0.577
Low myopia vs. normal vision
Energy density
TPFA
<803.55 Ref Ref Ref
≥803.55 1.25 (0.86–1.83) 0.235 1.22 (0.83–1.79) 0.298 1.12 (0.64–1.96) 0.679
n-3 PUFA
<759.65 Ref Ref Ref
≥759.65 1.07 (0.74–1.56) 0.705 1.05 (0.72–1.53) 0.797 0.93 (0.55–1.56) 0.773
ALA
<63.78 Ref Ref Ref
≥63.78 0.90 (0.60–1.33) 0.584 0.91 (0.62–1.35) 0.648 0.93 (0.63–1.37) 0.720
SDA
<0.75 Ref Ref Ref
≥0.75 1.12 (0.76–1.66) 0.551 1.12 (0.76–1.66) 0.550 1.11 (0.74–1.66) 0.612
EPA
<1.1 Ref Ref Ref
≥1.1 1.27 (0.84–1.91) 0.255 1.26 (0.84–1.90) 0.264 1.21 (0.79–1.87) 0.374
DPA
<0.82 Ref Ref Ref
≥0.82 1.16 (0.78–1.72) 0.449 1.15 (0.78–1.71) 0.469 1.13 (0.75–1.71) 0.551
DHA
<3.14 Ref Ref Ref
≥3.14 1.15 (0.78–1.72) 0.475 1.15 (0.78–1.71) 0.477 1.15 (0.77–1.71) 0.504

TPFA, total polyunsaturated fatty acid; OR, odds ratio; CI, confidence interval; Ref, reference; ALA, alpha-linolenic acid; SDA, octadecatetraenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; DHA, docosahexaenoic acid.

n-3 PUFAs include ALA, SDA, EPA, DPA, and DHA.

Model 1: univariate logistic regression; Model 2: adjusted the age and gender; Model 3: adjusted the age, sex, TPFA, and cotinine.