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SIRTs and metabolism of circadian rhythm. BMAL1, PER2, CLOCK are key circadian clock proteins. Acetylation and deacetylation of these key circadian clock proteins affect their activity to regulate circadian rhythm. SIRTs deacetylate these circadian clock proteins and maintain the homeostasis of circadian rhythm. These key circadian clock proteins regulate the circadian activity of NAMPT and NAD+ level, which in turn affect SIRTs’ activity as feedback.
