Table 1.
The localization and targets of SIRTs.
| SIRTs | Localization | Histone deacetylation target | Non-histone deacetylation target |
|---|---|---|---|
| SIRT1 | Nuclear/cytoplasm | H3K9, H4K16, H1K26 | PGC1a, FOXO1, AMPK, RelA, P65 Hif-1α, Hif-2α, MYC, ATG7 |
| SIRT2 | Nuclear/cytoplasm | H3K56, H4K16, H3K18 | AceCS2, SOD2, α-Tubulin, EIF5A, P53, G6PD, MYC, FOXO3a, FOXO1, ATG7 |
| SIRT3 | Mitochondrial | H3K56, H4K14 | SOD2, PDMC1a, IDH2, GOT2, FoxO3a, ATG5, ATG7, LC3B |
| SIRT4 | Mitochondrial | Unknown | GDH, PDH |
| SIRT5 | Mitochondrial | Unknown | CPS1 |
| SIRT6 | Nuclear | H3K9, H3K56 | gcn5, ctip |
| SIRT7 | Nuclear | H3K18 | UBF, RNA Pol I, HIF-1α, HIF-2α |