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. 2023 Jan 24;29(9):1719–1729. doi: 10.1158/1078-0432.CCR-22-2177

Figure 6.

Figure 6. bCNB scores predict patient outcomes and increase before radiographic detection of clinical progression. bCNB scores were generated for all 51 patients at baseline and during treatment via sequencing with PredicineCNB. A, Baseline bCNB scores were significantly higher in patients who experienced progression within 6 months (without clinical benefit; Wilcoxon test). B, High baseline bCNB scores were significantly associated with shorter PFS (log rank test). C, Serial analysis of bCNB during treatment revealed decreases at C1D15 and/or C2D1, followed by increases that preceded imaging detection of progressive disease in 12 of 18 (66.7%) of patients for whom staging blood samples were analyzed.

bCNB scores predict patient outcomes and increase before radiographic detection of clinical progression. bCNB scores were generated for all 51 patients at baseline and during treatment via sequencing with PredicineCNB. A, Baseline bCNB scores were significantly higher in patients who experienced progression within 6 months (without clinical benefit; Wilcoxon test). B, High baseline bCNB scores were significantly associated with shorter PFS (log rank test). C, Serial analysis of bCNB during treatment revealed decreases at C1D15 and/or C2D1, followed by increases that preceded imaging detection of progressive disease in 12 of 18 (66.7%) patients for whom staging blood samples were analyzed.