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. 2023 May 1;76(Suppl 2):S202–S209. doi: 10.1093/cid/ciad096

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The 24-hour change in Acinetobacter baumannii Astra research collection (ARC)2058 (ADC-99 [N379S]; oxacillinase [OXA]-259) CFU/mL relative to sulbactam time (T) > MIC (A), C_max/MIC (B), and AUC_0–24/MIC (C) based on data from a hollow-fiber in vitro infection model (O'Donnell et al., Unpublished data): (A) %T > MIC (r² = 0.82); (B) C_max/MIC (r² = 0.44); (C) AUC_0–24/MIC (r² = 0.67). Red diamond symbols represent PK parameter estimates derived from each dose fractionated regimen vs. the change in bacterial burden over 24 hours. The line represents the non-linear regression analysis of the data using the Hill equation. Abbreviations: AUC_0–24, area under the concentration-time curve over 0 to 24 hours; CFU, colony-forming units; C_max, maximum concentration; MIC, minimum inhibitory concentration.