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. 2023 May 1;76(Suppl 2):S202–S209. doi: 10.1093/cid/ciad096

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Change in bacterial burden (log₁₀ CFU/g) over 24 hours vs fAUC_0–24/MIC of durlobactam when administered in combination with sulbactam based on data from neutropenic murine thigh (r² = 0.86, n = 5 isolates) (A) and lung (r² = 0.91 n = 4 isolates) (B) infection models (O'Donnell et al., Unpublished data). Red diamond symbols represent PK parameter estimates derived from each dose fractionated regimen vs. the change inbacterial burden over 24 hours. The line represents the non-linear regression analysis of the data using the Hill equation. Abbreviations: CFU, colony-forming units; fAUC_0–24/MIC, ratio of unbound area under the concentration-time curve over 0 to 24 hours to the minimum inhibitory concentration.