Table 2.
Magnitude of Sulbactam fT > MIC Associated With 1- and 2-Log10 CFU Reductions From Baseline and EC80 Based on Data From In Vitro and In Vivo Studies
| Model | No. of Isolates | Sulbactam fT > MIC (%) by Endpoint | |||
|---|---|---|---|---|---|
| CFU Reduction From Baseline | EC80 | ||||
| r 2 | 1-Log10 | 2-Log10 | |||
| In vitro hollow fibera | 1 | 0.82 | 71.5 | 82.0 | 93.6 |
| In vivo thigh (4:1 dose)b | 6 | 0.83 | 29.9 | 38.2 | 44.1 |
| In vivo lung (4:1 dose)c | 5 | 0.89 | 41.2 | 53.5 | >100 |
| Mean ± SD | … | … | 47.5 ± 21.5 | 57.9 ± 22.2 | 68.9 ± 35.0 |
Data from reference (O'Donnell et al., Unpublished data). EC80, the percentage of time required for unbound concentrations to remain above the MIC in order to achieve 80% of the maximum activity.Abbreviations: CFU, colony-forming units; fT > MIC, time that unbound drug concentration remains above the minimum inhibitory concentration; SD, standard deviation
Sulbactam-sensitive isolate A. baumannii ARC2058.
Single pooled dataset Hill-type fitting across 6 A. baumannii isolates; sulbactam:durlobactam, 4:1.
Single pooled dataset Hill-type fitting across 5 A. baumannii isolates; sulbactam:durlobactam, 4:1.