Figure 2.

Ligand maps for compounds Z99, Z56 and EGC. The interaction key is shown on the right. Among notable contacts, all three compounds interact with R55, one of the key residues in the DNA binding site of RAD52. In contrast to EGC, however, whose interactions are dominated by van der Waals interaction and water-mediated contacts, Z99 and Z56 are involved in more direct interactions including hydrogen bonding.