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. 2023 Apr 18;66(8):6002–6009. doi: 10.1021/acs.jmedchem.3c00308

Figure 2.

Figure 2

Comparison of essential residues in linear laterocidamide and Oct-TriA1.15 Blue residues result in a 4- to 8-fold loss in activity against E. coli ATCC 25922 upon substitution with alanine, and red residues result in a 16-fold or greater loss.