Table 1. Activity of Linear Brevicidine and Laterocidine C-Terminal Analogue.
| Antibacterial
activity (μg/mL) |
% Hemolysis | ||||||
|---|---|---|---|---|---|---|---|
| Compound | E. coli ATCC 25922 | E. coli (MCR-1) | K. pneumoniae ATCC 13883 | A. baumannii ATCC 17961 | P. aeruginosa PAO1 | S. aureus USA300 | Sheep red blood cells |
| Brev (1) | 4 | 4 | 2 | 4 | 8 | >32 | <0.1 |
| Lat (2) | 2 | 2 | 2–4 | 2 | 4 | >32 | 1.3 |
| LL-OH (4) | 8 | 16 | 8–16 | 16 | 8 | >32 | <0.1 |
| LB-OH (5) | >32 | >32 | >32 | >32 | 16 | >32 | <0.1 |
| LL-NH2 (6) | 4 | 8 | 4–8 | 8 | 4 | >32 | <0.1 |
| LB-NH2 (7) | 16 | 16 | 16 | 16 | 4 | >32 | <0.1 |
| Δ13LL-NH2 (8) | 8 | 8 | 4–8 | 4 | 4 | >32 | <0.1 |
| Δ12LB-NH2 (9) | 8 | 16 | 8 | 8 | 4 | >32 | 3.8 |
| Δ12–13LL-NH2 (10) | 4 | 8 | 8–16 | 4 | 4 | >32 | 3.0 |
| Δ11–12LB-NH2 (11) | 4 | 4–8 | 2 | 8 | 2 | >32 | <0.1 |
| Δ11–13LL-NH2 (12) | 4 | 4 | 2 | 4 | 4 | 32 | 2.3 |
| Δ10–12LB-NH2 (13) | >32 | >32 | >32 | >32 | >32 | >32 | <0.1 |
| Δ10–13LL-NH2 (14) | >32 | 32 | >32 | 32 | >32 | >32 | <0.1 |
| Δ9–12LB-NH2 (15) | >32 | >32 | >32 | >32 | >32 | >32 | <0.1 |
| Δ9–13LL-NH2 (16) | >32 | >32 | >32 | 32 | >32 | >32 | <0.1 |