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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Science. 2023 Jan 12;379(6628):179–185. doi: 10.1126/science.ade1105

Fig. 4. Genomic editing of CaMKIIδ prevents cardiac cell death and fibrosis after IR.

Fig. 4.

(A) Immunohistochemistry of TUNEL (green, arrows), Hoechst 33342 (blue, for all nuclei), and cardiac troponin (recolored in purple for colorblind accessibility) in representative heart sections of mice subjected to sham surgery, IR, IR treated with a control AAV9, and IR treated with AAV-ABE-sgRNA6 (IR+Edit; scale bar 20 μm). (B) Mean percentage of TUNEL-positive cells in each group. (C) Whole transverse cross-sections of trichrome stained hearts for each group (scale bar 500 μm). (D) Mean percentage of fibrotic cardiac tissue in each group. Replicates are individual mice. Statistical comparisons are based on one-way ANOVA post-hoc corrected by Holm-Sidak. Data are presented as individual data points with means ± SEM.