Table A.3.
Results from meta-path discovery in NP-KG for natural product-drug pairs. Meta-path descriptions are available in Figure 4.
| Meta-path | Results |
|---|---|
| Green Tea – Raloxifene | |
| Green tea | Green tea constituent – Relation – Raloxifene | 1. EGCG inhibits raloxifene 2. EGCG coexists with raloxifene 3. EGCG interacts with raloxifene |
| Raloxifene – Relation – Green tea | Green tea constituent | No results |
| Green tea | Green tea constituent – Relation A – Enzyme or Transporter – Relation B – Raloxifene | No results |
| Green tea | Green tea constituent – Relation A – Enzyme or Transporter, Raloxifene – Relation B – Enzyme or Transporter | 1. Green tea inhibits UGT, Raloxifene inhibits/interacts with UGT 2. ECG inhibits UGT, Raloxifene inhibits/interacts with UGT 3. Catechin positively regulates/interacts with/directly regulates activity of UGT, Raloxifene inhibits/interacts with UGT 4. Catechin positively regulates CYP3A4, Raloxifene inhibits CYP3A4 5. EGCG inhibits/positively regulates UGT, Raloxifene inhibits/interacts with UGT 6. EGCG positively regulates CYP3A4, Raloxifene inhibits/interacts with UGT |
| Green Tea – Nadolol | |
| Green tea | Green tea constituent – Relation – Nadolol | 1. Green tea inhibits nadolol 2. EGCG inhibits nadolol 3. EGCG directly regulates activity of nadolol 4. Catechin interacts with nadolol |
| Nadolol – Relation – Green tea | Green tea constituent | 1. Nadolol positively regulates EGCG 2. Nadolol interacts with EGCG 3. Nadolol positively regulates catechin 4. Nadolol positively regulates green tea leaf |
| Green tea | Green tea constituent – Relation A – Enzyme or Transporter – Relation B – Nadolol | SLCO1A2 gene (OATP1A2) |
| Green tea | Green tea constituent – Relation A – Enzyme or Transporter, Nadolol – Relation B – Enzyme or Transporter | See Tables A.4 and A.5. |
| Kratom – Midazolam | |
| Kratom | Kratom constituent – Relation – Midazolam | No results |
| Midazolam – Relation – Kratom | Kratom constituent | 1. Mitragynine inhibits midazolam 2. Mitragynine positively regulates midazolam |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter – Relation B – Midazolam | No results |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter, Midazolam – Relation B – Enzyme or Transporter | 1. Mitragynine interacts with/inhibits/directly regulates activity of/directly positively regulates quantity of CYP3A4, Midazolam is substrate of/interacts with CYP3A4 2. Mitragynine inhibits/interacts with/positively regulates CYP2D6, Midazolam inhibits CYP2D6 3. Mitragynine inhibits/directly negatively regulates quantity of ABCB1, Midazolam interacts with ABCB1 |
| Kratom – Quetiapine | |
| Kratom | Kratom constituent – Relation – Quetiapine | No results |
| Quetiapine – Relation – Kratom | Kratom constituent | No results |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter – Relation B – Quetiapine | No results |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter, Quetiapine – Relation B – Enzyme or Transporter | 1. Mitragynine interacts with/inhibits/directly regulates activity of/directly positively regulates quantity of CYP3A4, Quetiapine is substrate of CYP3A4 2. Mitragynine inhibits/directly negatively regulates quantity of P-glycoprotein, Quetiapine transports P-glycoprotein |
| Kratom – Venlafaxine | |
| Kratom | Kratom constituent – Relation – Venlafaxine | No results |
| Venlafaxine – Relation – Kratom | Kratom constituent | No results |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter – Relation B – Venlafaxine | No results |
| Kratom | Kratom constituent – Relation A – Enzyme or Transporter, Venlafaxine – Relation B – Enzyme or Transporter | 1. Mitragynine interacts with/inhibits/directly regulates activity of/directly positively regulates quantity of CYP3A4, Venlafaxine is substrate of CYP3A4 2. Mitragynine inhibits/interacts with/positively regulates CYP2D6, Venlafaxine is substrate of/inhibits CYP2D6 |