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. 2023 May 1;23:388. doi: 10.1186/s12885-023-10847-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Effect of TROAP knockdown on melanoma cell proliferation and migration in vitro. A CCK-8 assays showed that TROAP inhibition reduced melanoma cells (A375 cell line and WM-115 cell line) proliferative ability in vitro. B, C Colony formation assay displayed cells with reduced TROAP expression exhibited a significant reduction in the numbers of colonies compared with the shRNA NC group. D EdU staining assay indicated that downregulation of TROAP expression repressed A375 cells and WM-115 cells proliferation. (Scale bar, 100 μm). E, F Scratch-wound healing assay indicated a significantly slower wound healing rate in cells with a reduced expression of TROAP (Scale bar, 100 μm). G Transwell assay showed that downregulation of TROAP expression inhibited the migration and invasion capacity of A375 cells and WM-115 cells (Scale bar, 250 μm). Note: *** P ≤ 0.001. ** P ≤ 0.01. * P ≤ 0.05