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. 2023 Apr 17;11:1129015. doi: 10.3389/fcell.2023.1129015

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Copyright © 2023 Mannion, Odell, Baker, Matthews, Jones and Cook.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Invasive and cancer stem cell phenotypes of MCAM expressing cells. (A) Invasion signature score (sInv) of the sEMT^low, sEMT^med and sEMT^high populations. (B) Cancer stem cell score (sCSC) of the sEMT^low, sEMT^med and sEMT^high populations. For (A,B), the graphs show the mean and standard deviation. Statistical analysis was performed using an unpaired, two-tailed Mann Whitney test; ****p < 0.0001, ns is not significant. (C) Mean sInv and sCSC of the sEMT^low, sEMT^med and sEMT^high populations further sub-divided according to MCAM gene expression. Cells with no detectable MCAM expression were identified and then MCAM expressing cells were divided into two equal sized groups of MCAM^low or MCAM^high cells. Spearman’s r for the data is shown. (D) Invasion signature score (sInv) and cancer stem cell score (sCSC) of the sEMT^highMCAM^low sub-population (n = 83) compared to all other malignant cells (n = 24,406).