Table 2.
Estimated univariate associations between ASD related outcomes and prenatal antidepressant and SSRI use
| Associations (exposed vs. unexposed groups for outcomes) | N-Total | N-Exposed | Coefficient/OR | LCL | UCL | P-value |
|---|---|---|---|---|---|---|
| SRS total raw score, N=1346 | ||||||
| Any antidepressant | 1339 | 76 | 6.4 | 1.0 | 11.9 | 0.02 |
| SSRI | 1214 | 50 | 6.5 | −0.3 | 13.3 | 0.06 |
| Medical reported any antidepressant | 118 | 8 | 11.4 | −12.0 | 34.9 | 0.34 |
| Medical reported SSRI | 120 | 7 | 14.3 | −11.4 | 39.9 | 0.28 |
| Self-reported any antidepressant | 1221 | 68 | 5.7 | 0.2 | 11.2 | 0.04 |
| Self-reported SSRI | 1094 | 43 | 5.1 | −1.7 | 12.0 | 0.14 |
| CBCL DSM-5 Autism t score for preschool children, N=1202 | ||||||
| Any antidepressant | 1199 | 63 | 1.0 | −0.7 | 2.6 | 0.25 |
| SSRI | 1072 | 38 | 2.2 | 0.1 | 4.4 | 0.04 |
| Medical reported any antidepressant | 59 | 6 | 1.1 | −3.7 | 6.0 | 0.65 |
| Medical reported SSRI | 58 | 5 | 2.0 | −3.3 | 7.2 | 0.47 |
| Self-reported any antidepressant | 1140 | 57 | 1.0 | −0.7 | 2.7 | 0.25 |
| Self-reported SSRI | 1014 | 33 | 2.4 | 0.1 | 4.7 | 0.04 |
| CBCL Autism Sum t score for school age children, N=546 | ||||||
| Any antidepressant | 546 | 35 | 5.0 | −0.3 | 10.3 | 0.07 |
| SSRI | 477 | 22 | 0.9 | −5.7 | 7.6 | 0.78 |
| Medical reported any antidepressant | 59 | <5 | NA | NA | NA | NA |
| Medical reported SSRI | 59 | <5 | NA | NA | NA | NA |
| Self-reported any antidepressant | 487 | 32 | 5.5 | 0.4 | 10.6 | 0.03 |
| Self-reported SSRI | 418 | 19 | 1.2 | −5.3 | 7.7 | 0.73 |
| ASD diagnosis, N=2384 | ||||||
| Any antidepressant | 2377 | 98 | 1.3 | 0.6 | 2.7 | 0.51 |
| SSRI | 2323 | 76 | 1.8 | 0.7 | 4.2 | 0.20 |
| Medical reported any antidepressant | 515 | 21 | 1.2 | 0.4 | 3.4 | 0.76 |
| Medical reported SSRI | 512 | 15 | 1.9 | 0.5 | 7.1 | 0.32 |
| Self-reported any antidepressant | 1862 | 77 | 1.4 | 0.5 | 4.1 | 0.49 |
| Self-reported SSRI | 1811 | 61 | 1.7 | 0.5 | 5.6 | 0.40 |
| M-CHAT, N=834 | ||||||
| Any antidepressant | 831 | 41 | 1.3 | 0.4 | 4.0 | 0.64 |
| SSRI | 761 | 23 | 1.0 | 0.2 | 4.5 | 0.98 |
| Medical reported any antidepressant | 42 | <5 | NA | NA | NA | NA |
| Medical reported SSRI | 42 | <5 | NA | NA | NA | NA |
| Self-reported any antidepressant | 789 | 37 | 1.7 | 0.5 | 5.5 | 0.35 |
| Self-reported SSRI | 719 | 19 | 1.5 | 0.3 | 7.6 | 0.60 |
a.
N, number of subjects; LCL, lower confidence limit; UCL, upper confidence limit; OR, odds ratio.
b.
SRS total raw score, CBCL DSM-5 Autism t score, CBCL Autism Sum t score are continuous outcomes. The estimated coefficient of exposure are given in the third column. ASD diagnosis and M-CHAT are binary outcomes. The estimated OR for each binary outcome variable comparing the exposed and unexposed groups are given in the third column.
c.
NA, not applicable. It represents that corresponding model did not converge or the estimations were too extreme to be true.