TABLE 2.

Genomics informed risk stratification guidelines for patients with LFS with a germline TP53 variant

High-risk variant TP53 carrier	Low-risk variant TP53 carrier
P/LP variant in a cancer gene	P/LP variants in the WNT signaling pathway
High probability of developing cancer using our epimutation cancer risk model	Low probability of developing cancer using our epimutation cancer risk model
High-risk epimutation cluster	Low-risk epimutation cluster
LEF1 hypermethylation	LEF1 hypomethylation