TABLE 1.
Antibiotic susceptibilities of wild-type M. tuberculosis, the ΔsigF mutant, and the complemented mutant
| Drug | MIC (μg/ml)a for indicated M. tuberculosis strain
|
||
|---|---|---|---|
| Wild type | ΔsigF mutantb | Complemented ΔsigF mutant | |
| Rifampin | 0.25 | 0.03125 | 0.625 |
| Rifapentine | 0.125 | 0.0625 | NDc |
| Isoniazid | 0.1 | 0.1 | ND |
| Ethambutol | 2.0 | 2.0 | ND |
| Streptomycin | 1.0 | 1.0 | ND |
| d-Cycloserine | 20 | 20 | ND |
a
MICs were determined by the Bactec method except for those for d-cycloserine, which were evaluated by agar dilution. Values are means of two to four determinations.
b
Values for rifampin and rifapentine represent eight- and twofold increases in susceptibility, respectively, with respect to the susceptibilities of the wild type.
c
ND, not done.