Table 2.
Baseline Patient Demographics and Clinical Characteristics
| Characteristic | Early Insulin Glargine (n = 58) | Late Insulin Glargine (n = 132) | p value |
|---|---|---|---|
| Age, mean ± SD, yr | 12.6 ± 3.7 | 12.1 ± 4.1 | 0.49 |
| Type 1 diabetes, n (%) | |||
| New diagnosis | 32 (55.2) | 68 (51.5) | 0.64 |
| Established diagnosis | 26 (44.8) | 64 (48.5) | 0.64 |
| HgbA1c, mean ± SD, %* | 12.9 ± 2.1 | 12.2 ± 1.9 | 0.04 |
| SCr, mean ± SD, mg/dL | 0.96 ± 0.4 | 0.89 ± 0.5 | 0.21 |
| K+, mean ± SD, mEq/L | 4.1 ± 0.8 | 4.3 ± 0.9 | 0.18 |
| BUN, mean ± SD, mg/dL | 15.0 ± 6.6 | 15.8 ± 8.6 | 0.49 |
| pH, mean ± SD | 7.1 ± 0.09 | 7.1 ± 0.11 | 0.78 |
| CO2, mean ± SD, mmol/L | 7.8 ± 2.5 | 7.1 ± 2.6 | 0.12 |
| Severity of DKA, n (%) | |||
| Moderate | 35 (60.3) | 64 (48.5) | 0.13 |
| Severe | 23 (39.7) | 68 (51.5) | 0.13 |
| Initial IV insulin infusion dose, mean ± SD, unit/kg/hr | 0.095 ± 0.01 | 0.092 ± 0.2 | 0.24 |
| Home insulin glargine dose, mean ± SD, unit/kg | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.35 |
| Time from admission to insulin glargine administration, mean ± SD, hr† | 1.8 ± 3.4 | 24.4 ± 13.8 | <0.001 |
BUN, blood urea nitrogen; CO2, carbon dioxide; DKA, diabetic ketoacidosis; IV, intravenous; HgbA1c, hemoglobin A1c; K+, serum potassium; SCr, serum creatinine
* HgbA1c values were only available for 49 patients in the early insulin glargine group and 117 patients in the late insulin glargine group.
† In the early insulin glargine group, the range of time from admission to insulin glargine administration was prior to admission (0 hours) to 5.8 hours. In the late insulin glargine group, the range was 6.4 to 106.5 hours.