Figure 2.

Plasma prorenin/renin, ANG II, and soluble prorenin receptor (sPRR) in normal fat diet (NFD) and high-fat diet (HFD) mice. Plasma total renin/prorenin was increased in male HFD compared with NFD (A). Plasma ANG II levels were significantly increased in male HFD compared with NFD mice (B). In male HFD mice, plasma sPRR was higher than in age-matched NFD mice after 24 wk on diet (C). No changes were observed in females compared with NFD vs. HDF (D). Significant findings from two-way ANOVA are listed on each graph along with results of Sidak’s post hoc tests. **P < 0.001, *P < 0.05. Values are represented as means ± SD.