Table 1.
Responses of sham and ovariectomized mice before surgery, during heat exposure, and recovery
| Parameter | Sham | OVX | P Value |
|---|---|---|---|
| Surgery | |||
| Body mass pre surgery, g | 21.6 ± 0.7 | 19.9 ± 3.2 | 0.138 |
| Heat exposure | |||
| Body mass pre EHS, g | 25.4 ± 1.1 (n = 8) | 28.2 ± 1.5 (n = 10) | <0.001* |
| Body surface area, cm2 | 84.8 ± 2.3 (n = 8) | 91.8 ± 3.0 (n = 10) | <0.001* |
| BSA/mass, cm2/g | 3.3 ± 0.04 (n = 8) | 3.2 ± 0.05 (n = 10) | <0.001* |
| Tc,max, °C | 42.2 ± 0.5 (n = 8) | 42.2 ± 0.3 (n = 10) | 0.895 |
| Time to Tc,max, min | 126.3 ± 21 (n = 8) | 99.1 ± 19.8 (n = 10) | 0.013* |
| Thermal load, AUC | 138.4 ± 47.9 (n = 8) | 117.5 ± 25.6 (n = 10) | 0.253 |
| Distance ran, m | 753 ± 188 (n = 8) | 528 ± 163 (n = 10) | 0.015* |
| Recovery | |||
| Body mass post EHS, g | 23.5 ± 0.8 (n = 8) | 26.7 ± 1.6 (n = 8) | <0.001* |
| Dehydration, % | 7.4% ± 1.7% (n = 8) | 6.5% ± 1.4% (n = 8) | 0.276 |
| Time to hypothermia, min | 25.4 ± 4.1 (n = 8) | 33.2 ± 9.72 (n = 8) | 0.052 |
| Depth of hypothermia, °C | 31.45 ± 1.0 (n = 8) | 30.8 ± 3.2 (n = 8) | 0.606 |
Maximal core temperature at loss of consciousness (Tc, max). BSA, body surface area; EHS, exertional heat stroke; OVX, ovariectomy. *P < 0.05.