Table 2. Localised RMS with FOXO1 fusions.
| Univariate analysis | |||||
|---|---|---|---|---|---|
| Prognostic variables & categories | EFS | OS | |||
| 5 year (95% CI) | p-value | 5 year (95% CI) | p-value | ||
| Overall | 55.13% (45.55–63.70) | NA | 63.68% (53.59–72.14) | NA | |
| Age | |||||
| <10 years | 44.63% (27.04–60.79) | 0.198 | 63.65% (53.01–72.50) | 0.407 | |
| ≥10 years | 58.92% (47.48–68.69) | 62.52% (29.93–83.29) | |||
| Histology | |||||
| Embryonal | 54.58% (42.42–65.22) | 0.946 | 59.68% (46.83–70.39) | 0.238 | |
| Alveolar | 56.04% (38.95–70.06) | 65.31% (45.79–79.26) | |||
| Others | 53.33% (6.83–86.31) | 100.00% | |||
| Fusion status | |||||
| FOXO1 positive | 44.63% (27.04–60.79) | 0.296 | 65.89% (45.94–79.95) | 0.603 | |
| FOXO1 negative | 58.92% (47.48–68.69) | 62.30% (49.86–72.49) | |||
| Site | |||||
| Favourable | 67.52% (49.09–80.51) | 0.063 | 77.16% (58–88.39) | 0.044 | |
| Unfavourable | 53.05% (41.87–63.03) | 58.00% (45.93–68.29) | |||
| Site & fusion | |||||
| Favourable – FOXO1 positive | 45.83% (16.89–71.02) | 0.063 | 73.33% (37.90–90.56) | 0.637 | |
| Favourable – FOXO1 negative | 75.10% (50.24–88.77) | 76.51% (47.48–90.82) | |||
| Unfavourable – FOXO1 positive | 42.10% (20.20–62.64) | 0.807 | 60.74% (34.24–79.29) | 0.661 | |
| Unfavourable – FOXO1 negative | 52.06% (38.85–63.71) | 56.76% (42.90–68.45) | |||
| Tumour size | |||||
| <5 cm | 71.59% (58.03–81.44) | <0.0001 | 81.94% (69.65–89.62) | <0.0001 | |
| 5–10 cm | 52.53% (37.30–65.68) | 62.22% (45.92–74.88) | |||
| >10 cm | 0.00% | 0.00% | |||
| Nodal status | |||||
| N0 | 64.02% (51.98–73.78) | 0.005 | 74.38% (62.37–83.07) | 0.002 | |
| N1 | 40.33% (25.08–55.09) | 45.73% (28.65–61.28) | |||
| Risk | |||||
| Low (A) | 72.22% (41.72–88.59) | 0.45 | 86.67% (56.39–96.49) | 0.25 | |
| Low (B) | 45.08% (13.6–72.75) | 52.6% (16.34–79.62) | |||
| Intermediate | 53.29% (42.48–62.97) | 61.5% (50.13–71.01) | |||
| Revised risk | |||||
| Low | 80.81% (42.35–94.85) | 0.127 | 90.91% (50.81–98.67) | 0.105 | |
| Intermediate | 52.61% (42.54–61.71) | 61.12% (50.43–70.19) | |||
| Multivariate analysis | |||||
| Covariate | Hazard ratio | p-value | Hazard ratio | p-value | |
| Nodal status | |||||
| N0 | Reference | ||||
| NI | 1.58 (0.903–2.763) | 0.109 | 1.803 (0.951–3.418) | 0.071 | |
| Tumour size | |||||
| <5 cms | Reference | ||||
| 5–10 cms | 1.535 (0.790–2.983) | 0.207 | 1.566 (0.703–3.505) | 0.275 | |
| >10 cms | 3.747 (1.741–8.062) | 0.001 | 4.494 (1.878–10.754) | 0.001 | |
| Site | |||||
| Favourable | Reference | ||||
| Unfavourable | 1.424 (0.72–2.814) | 0.31 | 1.635 (0.718–3.724) | 0.242 | |