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. 2023 May 1;13:8. doi: 10.1038/s41387-023-00236-4

Table 3.

Association between FAs and the risk of IGT and T2DM in NHANES 2013–2016a,b.

FAs(g/d) IGT T2DM
aORa 95%CI Pb aORa 95%CI Pb
Model 1
TFA 0.996 0.994–0.999 0.008 0.997 0.994–0.999 0.115
TSFA 0.989 0.983–0.995 <0.001 0.995 0.987–1.002 0.377
4:0 0.759 0.630–0.914 0.010 0.933 0.753–1.157 0.762
6:0 0.722 0.528–0.989 0.074 0.970 0.704–1.337 0.893
8:0 0.560 0.384–0.817 0.010 0.844 0.604–1.179 0.564
10:0 0.680 0.545–0.850 0.005 0.858 0.686–1.074 0.378
12:0 0.912 0.825–1.008 0.101 0.921 0.820–1.034 0.377
14:0 0.898 0.850–0.948 <0.001 0.971 0.911–1.033 0.575
16:0 0.979 0.968–0.990 <0.001 0.989 0.975–1.003 0.345
18:0 0.957 0.935–0.979 <0.001 0.985 0.957–1.013 0.539
MUFA 0.992 0.987–0.998 0.013 0.993 0.986–0.999 0.125
16:1 0.850 0.762–0.948 0.010 0.973 0.850–1.115 0.852
18:1 0.991 0.985–0.997 0.012 0.992 0.985–0.999 0.115
20:1 0.728 0.491–1.079 0.146 0.543 0.328–0.900 0.115
22:1 0.789 0.419–1.484 0.531 0.910 0.555–1.492 0.852
PUFA 0.992 0.984–1.001 0.101 0.984 0.972–0.995 0.069
 n-6
18:2 0.990 0.981–0.999 0.076 0.981 0.969–0.994 0.069
18:3 0.903 0.835–0.977 0.021 0.871 0.768–0.987 0.115
18:4 0.267 0.054–1.328 0.145 0.346 0.023–5.219 0.679
20:4 1.246 0.592–2.622 0.617 1.069 0.406–2.815 0.893
 n-3
20:5 0.855 0.401–1.825 0.717 1.163 0.475–2.851 0.852
22:5 0.212 0.011–4.032 0.366 0.731 0.018–29.015 0.893
 22:6 0.994 0.632–1.562 0.979 1.156 0.648–2.061 0.843
Model 2
TFA 0.998 0.995–1.000 0.081 0.998 0.996–1.001 0.664
TSFA 0.992 0.985–0.999 0.047 1.000 0.992–1.007 0.980
4:0 0.815 0.669–0.994 0.066 1.023 0.819–1.276 0.980
8:0 0.634 0.437–0.920 0.047 0.969 0.714–1.313 0.980
10:0 0.722 0.572–0.911 0.047 0.922 0.738–1.151 0.944
14:0 0.927 0.875–0.983 0.047 1.014 0.952–1.080 0.980
16:0 0.987 0.974–0.999 0.066 1.000 0.986–1.015 0.984
18:0 0.970 0.945–0.996 0.047 1.005 0.977–1.035 0.980
MUFA 0.995 0.989–1.001 0.140 0.996 0.989–1.003 0.664
16:1 0.956 0.844–1.083 0.482 1.149 0.995–1.327 0.347
18:1 0.995 0.988–1.001 0.140 0.996 0.989–1.003 0.664
 n-6
 18:3 0.908 0.837–0.985 0.047 0.873 0.774–0.986 0.345
Model 3
TSFA 0.991 0.985–0.998 0.024 0.998 0.990–1.006 0.919
 8:0 0.665 0.455–0.972 0.035 1.036 0.752–1.426 0.919
 10:0 0.755 0.594–0.959 0.025 0.988 0.787–1.241 0.919
 14:0 0.931 0.877–0.987 0.024 1.017 0.955–1.084 0.919
 18:0 0.965 0.941–0.991 0.024 0.996 0.966–1.027 0.919
 n-6
 18:3 0.902 0.831–0.980 0.024 0.877 0.780–0.987 0.177

aData are aORs, 95% CIs were calculated. Model 1: unadjusted model; Model 2: adjusted for age, sex; Model 3: adjusted for age, sex, race, BMI, education, ratio of family income to poverty, smoking, exercise and hypertension.

bP value corrected by FDR.