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. 2023 May 1;13:8. doi: 10.1038/s41387-023-00236-4

Table 4.

Association of different FAs ranges and risk of IGT in NHANESa,b.

FAs(g/d) Q2a Pb Q3a Pb Q4a Pb
Model 1
TFA 0.935 (0.747–1.169) 0.596 0.730 (0.592–0.901) 0.014 0.709 (0.575–0.874) 0.007
TSFA 0.902 (0.736–1.106) 0.386 0.770 (0.628–0.943) 0.032 0.634 (0.506–0.795) 0.001
  4:0 0.882 (0.724–1.076) 0.304 0.712 (0.593–0.853) 0.002 0.668 (0.535–0.835) 0.003
  6:0 0.875 (0.703–1.089) 0.314 0.697 (0.578–0.840) 0.002 0.714 (0.573–0.890) 0.013
  8:0 0.902 (0.716–1.136) 0.443 0.758 (0.616–0.932) 0.027 0.634 (0.509–0.790) 0.001
  10:0 0.923 (0.733–1.164) 0.555 0.796 (0.662–0.956) 0.037 0.619 (0.491–0.779) 0.001
  12:0 0.818 (0.649–1.031) 0.135 0.702 (0.553–0.890) 0.014 0.685 (0.547–0.859) 0.007
  14:0 0.970 (0.785–1.199) 0.804 0.743 (0.613–0.900) 0.012 0.598 (0.476–0.751) 0.001
  16:0 0.889 (0.722–1.095) 0.352 0.842 (0.692–1.025) 0.135 0.658 (0.530–0.818) 0.002
  18:0 0.892 (0.719–1.107) 0.370 0.890 (0.735–1.076) 0.314 0.650 (0.526–0.802) 0.001
MUFA 0.914 (0.720–1.161) 0.531 0.783 (0.632–0.969) 0.051 0.732 (0.587–0.913) 0.020
  16:1 0.906 (0.744–1.103) 0.386 0.844 (0.687–1.036) 0.157 0.774 (0.626–0.955) 0.039
  18:1 0.849 (0.667–1.080) 0.261 0.804 (0.648–0.996) 0.086 0.691 (0.556–0.858) 0.006
  20:1 1.010 (0.797–1.279) 0.937 0.835 (0.689–1.011) 0.115 0.783 (0.627–0.977) 0.062
  22:1 0.892 (0.724–1.098) 0.358 0.791 (0.653–0.957) 0.037 0.872 (0.715–1.062) 0.254
PUFA 0.799 (0.648–0.984) 0.066 0.791 (0.648–0.965) 0.047 0.781 (0.629–0.969) 0.051
 n-6
  18:2 0.794 (0.642–0.981) 0.064 0.770 (0.631–0.939) 0.030 0.754 (0.603–0.944) 0.036
  18:3 0.851 (0.711–1.019) 0.127 0.773 (0.629–0.951) 0.037 0.740 (0.596–0.917) 0.021
  18:4 0.926 (0.752–1.141) 0.532 0.800 (0.636–1.006) 0.102 0.785 (0.652–0.946) 0.031
  20:4 0.890 (0.720–1.102) 0.359 0.892 (0.728–1.093) 0.352 0.938 (0.762–1.155) 0.596
n-3
  20:5 0.828 (0.674–1.017) 0.123 0.736 (0.607–0.893) 0.010 0.822 (0.662–1.020) 0.127
  22:5 0.839 (0.691–1.019) 0.127 0.762 (0.624–0.930) 0.025 0.711 (0.565–0.896) 0.014
  22:6 0.979 (0.792–1.211) 0.858 1.033 (0.824–1.294) 0.804 1.053 (0.831–1.334) 0.713
Model 2
TFA 0.954 (0.756–1.204) 0.742 0.795 (0.636–0.993) 0.138 0.802 (0.633–1.016) 0.174
TSFA 0.886 (0.713–1.102) 0.406 0.799 (0.642–0.994) 0.138 0.705 (0.545–0.910) 0.055
  4:0 0.876 (0.715–1.074) 0.347 0.745 (0.611–0.908) 0.040 0.711 (0.564–0.897) 0.040
  6:0 0.868 (0.686–1.098) 0.388 0.718 (0.587–0.879) 0.020 0.750 (0.593–0.948) 0.089
  8:0 0.901 (0.713–1.139) 0.490 0.780 (0.621–0.979) 0.130 0.674 (0.537–0.846) 0.020
  10:0 0.911 (0.713–1.165) 0.530 0.814 (0.672–0.985) 0.130 0.644 (0.506–0.821) 0.020
  12:0 0.836 (0.655–1.066) 0.275 0.715 (0.554–0.924) 0.069 0.722 (0.572–0.912) 0.054
  14:0 0.982 (0.788–1.225) 0.874 0.789 (0.64–0.967) 0.103 0.675 (0.530–0.858) 0.020
  16:0 0.919 (0.735–1.149) 0.530 0.913 (0.740–1.128) 0.499 0.761 (0.597–0.971) 0.119
  18:0 0.898 (0.718–1.124) 0.454 0.930 (0.757–1.142) 0.552 0.740 (0.582–0.940) 0.083
MUFA 0.931 (0.727–1.192) 0.628 0.851 (0.677–1.070) 0.296 0.8332 (0.649–1.069) 0.275
  16:1 0.946 (0.779–1.149) 0.628 0.962 (0.781–1.185) 0.755 0.966 (0.760–1.227) 0.801
  18:1 0.879 (0.687–1.125) 0.417 0.883 (0.700–1.114) 0.415 0.798 (0.625–1.020) 0.174
  22:1 0.893 (0.716–1.113) 0.417 0.810 (0.664–0.989) 0.136 0.892 (0.727–1.094) 0.406
PUFA 0.818 (0.658–1.018) 0.174 0.857 (0.695–1.055) 0.275 0.862 (0.677–1.098) 0.382
 n-6
  18:2 0.842 (0.670–1.058) 0.275 0.850 (0.687–1.050) 0.273 0.866 (0.674–1.113) 0.402
  18:3 0.852 (0.713–1.019) 0.177 0.813 (0.653–1.011) 0.174 0.761 (0.603–0.960) 0.103
  18:4 0.972 (0.788–1.200) 0.808 0.909 (0.714–1.159) 0.530 0.892 (0.731–1.089) 0.402
 n-3
  20:5 0.886 (0.706–1.112) 0.415 0.820 (0.671–1.002) 0.157 0.915 (0.739–1.132) 0.504
  22:5 0.842 (0.690–1.027) 0.193 0.826 (0.670–1.018) 0.174 0.805 (0.633–1.025) 0.177
Model 3
  4:0 0.895 (0.728–1.101) 0.367 0.784 (0.638–0.965) 0.064 0.755 (0.589–0.969) 0.069
  6:0 0.862 (0.683–1.088) 0.289 0.747 (0.605–0.921) 0.024 0.762 (0.594–0.977) 0.069
  8:0 0.927 (0.729–1.179) 0.577 0.791 (0.624–1.001) 0.088 0.701 (0.550–0.894) 0.021
  10:0 0.911 (0.712–1.166) 0.531 0.840 (0.689–1.024) 0.127 0.662 (0.510–0.860) 0.021
  14:0 0.997 (0.791–1.255) 0.976 0.810 (0.655–1.003) 0.088 0.688 (0.534–0.887) 0.021

aData are adjusted OR (aOR), 95% CIs were calculated. Q quintile; Quintile 1 was the referent that was concealed. Model 1: unadjusted model; Model 2: adjusted for age, sex; Model 3: adjusted for age, sex, race, BMI, education, ratio of family income to poverty, smoking, exercise and hypertension.

bP value corrected by FDR.