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. 2023 May 1;13:7073. doi: 10.1038/s41598-023-32922-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Glucose-mediated regulation of cholesterol metabolism may play a role in cNCC programmed cell death. (A) Apoptosis in cNCC cultured in HG, CG, NG, and NG2P conditions plotted as a function of glucose availability to examine the effects of cholesterol synthesis inhibition, was measured via the Incucyte live-cell Casp3/7 apoptosis assay. n = 6 wells/condition; multiple images per well were collected for 3d. (B), Apoptosis in cNCC cultured in HG, CG, NG, and NG2P conditions in the absence (vehicle) or presence of 10 μM fatostatin or fluvastatin was measured via the Incucyte live-cell Casp3/7 apoptosis assay. Each bar represents means ± SD. ****p < 0.0001.