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. 2023 May 1;13:7073. doi: 10.1038/s41598-023-32922-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased cholesterol synthesis shifts cNCC terminal fate away from chondrogenesis. (A) Alcian blue staining of cNCC cultured in chondrogenesis medium in HG and CG conditions in the presence of vehicle or 5 µM fatostatin and fluvastatin. Scale bars are 50 µM. (B) Spectrophotometric quantification of panel A images (4cm² sample wells, n = 5 per group). (C) Total cholesterol levels normalized to protein in cNCC cultured in chondrogenesis medium under the specified conditions (n = 3 per group). Each bar represents mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.