TABLE 1.
Ga(NO3)3 kills M. tuberculosis growing within human macrophagesa
| Test group | Mean CFU ± SD at (days post-Ga):
|
|||||
|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | 10 | |
| Control | (4.3 ± 0.4) × 104 | (8.0 ± 1.7) × 104 | (2.2 ± 0.3) × 105 | (3.6 ± 0.6) × 105 | (6.4 ± 0.3) × 105 | (1.2 ± 0.0) × 106 |
| Ga(NO3)3 | (1.2 ± 0.2) × 104 | (7.3 ± 1.8) × 103 | (6.0 ± 0.1) × 103 | (3.0 ± 0.0) × 103 | (6.3 ± 1.8) × 102 | |
a
Data represent the mean ± the SD of duplicate samples from a representative experiment (n = 3). Harvested combined supernatants and cell lysates from wells were plated on 7H11 agar in serial dilutions, and CFU were counted after 2 weeks.