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. 1993 Aug;56(8):878–884. doi: 10.1136/jnnp.56.8.878

Neuropsychological abnormalities in AIDS and asymptomatic HIV seropositive patients.

G Villa 1, D Monteleone 1, C Marra 1, A Bartoli 1, A Antinori 1, F Pallavicini 1, E Tamburrini 1, I Izzi 1
PMCID: PMC1015142  PMID: 8350104

Abstract

Neuropsychological and immunological parameters were studied in 36 AIDS patients with early disease and without clinical, laboratory, and neuroradiological signs of CNS impairment, and also in 33 asymptomatic HIV seropositive subjects. Many AIDS patients performed abnormally on timed psychomotor tasks, tasks involving sequencing and "set-shifting", and memory tasks stressing attention, learning, active retrieval, and monitoring of information. Asymptomatic HIV seropositive subjects as a group did not perform significantly worse than controls. However, on the basis of a cut off number of pathological performances on neuropsychological tasks, 52.8% of AIDS and 30.3% of asymptomatic HIV seropositive subjects had cognitive impairment, compared with 3.9% of HIV seronegative controls. Low values of CD4+ cells and of CD4+/CD8+ ratio and high titres of P-24 antigen in the blood prevailed among subjects with cognitive impairment, especially in the asymptomatic HIV seropositive group.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Caltagirone C., Gainotti G., Masullo C., Miceli G. Validity of some neuropsychological tests in the assessment of mental deterioration. Acta Psychiatr Scand. 1979 Jul;60(1):50–56. doi: 10.1111/j.1600-0447.1979.tb00264.x. [DOI] [PubMed] [Google Scholar]
  2. Cummings J. L., Benson D. F. Subcortical dementia. Review of an emerging concept. Arch Neurol. 1984 Aug;41(8):874–879. doi: 10.1001/archneur.1984.04050190080019. [DOI] [PubMed] [Google Scholar]
  3. Fahey J. L., Taylor J. M., Detels R., Hofmann B., Melmed R., Nishanian P., Giorgi J. V. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990 Jan 18;322(3):166–172. doi: 10.1056/NEJM199001183220305. [DOI] [PubMed] [Google Scholar]
  4. Fauci A. S., Schnittman S. M., Poli G., Koenig S., Pantaleo G. NIH conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann Intern Med. 1991 Apr 15;114(8):678–693. doi: 10.7326/0003-4819-114-8-678. [DOI] [PubMed] [Google Scholar]
  5. Fauci A. S. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science. 1988 Feb 5;239(4840):617–622. doi: 10.1126/science.3277274. [DOI] [PubMed] [Google Scholar]
  6. Field M., Tate J., Kunze H., Frazer I. H. Cerebral dysfunction with evidence of cerebral HIV infection amongst asymptomatic HIV seropositive subjects. Aust N Z J Med. 1989 Dec;19(6):694–699. doi: 10.1111/j.1445-5994.1989.tb00337.x. [DOI] [PubMed] [Google Scholar]
  7. Gallo P., Frei K., Rordorf C., Lazdins J., Tavolato B., Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J Neuroimmunol. 1989 Jul;23(2):109–116. doi: 10.1016/0165-5728(89)90029-5. [DOI] [PubMed] [Google Scholar]
  8. Goethe K. E., Mitchell J. E., Marshall D. W., Brey R. L., Cahill W. T., Leger G. D., Hoy L. J., Boswell R. N. Neuropsychological and neurological function of human immunodeficiency virus seropositive asymptomatic individuals. Arch Neurol. 1989 Feb;46(2):129–133. doi: 10.1001/archneur.1989.00520380029008. [DOI] [PubMed] [Google Scholar]
  9. Grant I., Atkinson J. H., Hesselink J. R., Kennedy C. J., Richman D. D., Spector S. A., McCutchan J. A. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging. Ann Intern Med. 1987 Dec;107(6):828–836. doi: 10.7326/0003-4819-107-6-828. [DOI] [PubMed] [Google Scholar]
  10. Hollander H., Levy J. A. Neurologic abnormalities and recovery of human immunodeficiency virus from cerebrospinal fluid. Ann Intern Med. 1987 May;106(5):692–695. doi: 10.7326/0003-4819-106-5-692. [DOI] [PubMed] [Google Scholar]
  11. Lacey J. N., Forbes M. A., Waugh M. A., Cooper E. H., Hambling M. H. Serum beta 2-microglobulin and human immunodeficiency virus infection. AIDS. 1987 Jul;1(2):123–127. [PubMed] [Google Scholar]
  12. Miller E. N., Selnes O. A., McArthur J. C., Satz P., Becker J. T., Cohen B. A., Sheridan K., Machado A. M., Van Gorp W. G., Visscher B. Neuropsychological performance in HIV-1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS) Neurology. 1990 Feb;40(2):197–203. doi: 10.1212/wnl.40.2.197. [DOI] [PubMed] [Google Scholar]
  13. Navia B. A., Jordan B. D., Price R. W. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986 Jun;19(6):517–524. doi: 10.1002/ana.410190602. [DOI] [PubMed] [Google Scholar]
  14. Phillips A. N., Lee C. A., Elford J., Janossy G., Timms A., Bofill M., Kernoff P. B. Serial CD4 lymphocyte counts and development of AIDS. Lancet. 1991 Feb 16;337(8738):389–392. doi: 10.1016/0140-6736(91)91166-r. [DOI] [PubMed] [Google Scholar]
  15. Selnes O. A., Miller E., McArthur J., Gordon B., Muñoz A., Sheridan K., Fox R., Saah A. J. HIV-1 infection: no evidence of cognitive decline during the asymptomatic stages. The Multicenter AIDS Cohort Study. Neurology. 1990 Feb;40(2):204–208. doi: 10.1212/wnl.40.2.204. [DOI] [PubMed] [Google Scholar]
  16. Stern Y., Marder K., Bell K., Chen J., Dooneief G., Goldstein S., Mindry D., Richards M., Sano M., Williams J. Multidisciplinary baseline assessment of homosexual men with and without human immunodeficiency virus infection. III. Neurologic and neuropsychological findings. Arch Gen Psychiatry. 1991 Feb;48(2):131–138. doi: 10.1001/archpsyc.1991.01810260039006. [DOI] [PubMed] [Google Scholar]
  17. Tross S., Price R. W., Navia B., Thaler H. T., Gold J., Hirsch D. A., Sidtis J. J. Neuropsychological characterization of the AIDS dementia complex: a preliminary report. AIDS. 1988 Apr;2(2):81–88. doi: 10.1097/00002030-198804000-00002. [DOI] [PubMed] [Google Scholar]
  18. Wilkie F. L., Eisdorfer C., Morgan R., Loewenstein D. A., Szapocznik J. Cognition in early human immunodeficiency virus infection. Arch Neurol. 1990 Apr;47(4):433–440. doi: 10.1001/archneur.1990.00530040085022. [DOI] [PubMed] [Google Scholar]
  19. Zung W. W. A rating instrument for anxiety disorders. Psychosomatics. 1971 Nov-Dec;12(6):371–379. doi: 10.1016/S0033-3182(71)71479-0. [DOI] [PubMed] [Google Scholar]
  20. Zung W. W., Richards C. B., Short M. J. Self-rating depression scale in an outpatient clinic. Further validation of the SDS. Arch Gen Psychiatry. 1965 Dec;13(6):508–515. doi: 10.1001/archpsyc.1965.01730060026004. [DOI] [PubMed] [Google Scholar]
  21. de Wolf F., Goudsmit J., Paul D. A., Lange J. M., Hooijkaas C., Schellekens P., Coutinho R. A., van der Noordaa J. Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia. Br Med J (Clin Res Ed) 1987 Sep 5;295(6598):569–572. doi: 10.1136/bmj.295.6598.569. [DOI] [PMC free article] [PubMed] [Google Scholar]

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