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. 2023 Apr 18;14:1144946. doi: 10.3389/fmicb.2023.1144946

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Copyright © 2023 Cui, Yu, Xu, Liu, Wang, Li, Kong, Zhang, Jiang, Giuliodori, Fabbretti, He and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OM19r transported to cytoplasm by the SbmA protein on bacterial inner membrane. (A) The mRNA expression of SbmA gene increased after OM19r and OM19r combined with GEN against E. coli B2. (B) SDS-PAGE results of SbmA protein. M: Premixed Protein Marker(low), 1: flow through 2: 50 mM imidazole wash, 3: 100 mM imidazole wash, 4: 300 mM imidazole first wash, 5: 300 mM imidazole second wash. (C) Effect of SbmA on the antibacterial activity of OM19r and colistin against E. coli B2 was determined by adding SbmA protein in vitro. (D) Effect of SbmA on the FIC of OM19r combined with GEN against E. coli B2 was determined by adding SbmA protein in vitro. (E) FIC of OM19r combined with GEN against E.coli ATCC25922 (△SbmA) was determined in vitro. (F) Molecular docking results of both OM19r and SbmA protein binding.