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Deconvolutional analysis of end motifs of mouse plasma cfDNA samples that were subjected to whole blood in vitro incubation. (A) F-profile II (DNASE1) levels in plasma cfDNA from WT mice before and after 6 h incubation in heparin-contained tube, and from Dnase1−/− mouse before and after 6 h heparin incubation. (B) F-profile III (DFFB) levels in plasma cfDNA from WT mice before and after 6 h incubation in EDTA-contained tube, and from Dffb−/− mice before and after 6 h EDTA incubation.
